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During the first 2�years, 1,623�subjects received monotherapy with Avodart; 1,611�subjects received monotherapy with tamsulosin; and 1,610�subjects received combination therapy. The relationship between long-term use of Avodart and male breast neoplasia is currently unknown. If clinicians elect to use percent free PSA as an aid in the detection of prostate cancer in men receiving Avodart, no adjustment to its value appears necessary. Therefore, for interpretation of serial PSAs in a man taking Avodart, a new baseline PSA concentration should be established after 3�to 6�months of treatment, and this new value should be used to assess potentially cancer-related changes in PSA. Because of the potential for drug-drug interactions, use caution when prescribing Avodart to patients taking potent, chronic CYP3A4 enzyme inhibitors (e. Over 2�years of treatment, drug-related ejaculation disorders occurred more frequently in subjects receiving combination therapy (9%) compared to Avodart (2%) or tamsulosin (3%) as monotherapy.

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